[Solved]: A patient is taking digoxin for heart failure (P-gp…

A patient is taking digoxin for heart failure (P-gp substrate; 25% protein bound). The provider decides to start bupropion for smoking cessation (CYP2D6 inhibitor; 84% protein bound). Group of answer choices Bupropion may bind and prevent the absorption of digoxin resulting in decreased therapeutic effect of digoxin. Bupropion may displace protein bound digoxin leading to increased therapeutic effect of digoxin. Bupropion may induce the metabolism of digoxin leading to decreased therapeutic effect of digoxin. Bupropion may inhibit the metabolism of digoxin leading to increased therapeutic effect of digoxin. There is no drug interaction between digoxin and bupropion.