A 45 yo patient with a PMH of hypertension, anemia, and dyslipidemia presents to the pharmacy with a prescription for levofloxacin 750 mg po daily x 5 days for a sinus infection. Current medication profile includes: Hydrochlorothiazide 25 mg PO daily (hypertension) Amlodipine 10 mg PO daily (CYP3A4 substrate, CYP3A4 inhibitor) (hypertension) Atorvastatin 00 mg PO daily (P-gp substrate) (dyslipidemia) Ferrous sulfate 325 mg PO TID (anemia) 1. What potential drug interactions are there with this new prescription? 2. What is the mechanism of these interactions? 3. How would you manage these interactions?
[Verified Answer]: A 45 yo patient with a PMH of…
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