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Imagine a drug with kEL = 1.2 hr-1, clearance = 14.4 L/hr, and VD = 12 L/kg. In order to achieve a steady-state plasma concentration of 2 mg/L, how large should each maintenance dose be if a 30 kg patient is going to take an oral dose every 12 hours. Assume 100% bioavailability and first-order metabolism.
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