Drug B is administered by repeated IV bolus injections with a dosing interval of 12 hours. After steady-state is achieved the plasma concentrations were as follows: CmaxSS = 50 mg/L, CminSS = 25 mg/L. The Vd for Drug B = 20 L. Assume 1st order elimination and 1-compartment model. (i) What is the Dose required to achieve such peak and trough at steady state. (ii) What is the ke of the drug?
Drug B is administered by repeated IV bolus injections with a dosing interval of 12 hours
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